ESPE Abstracts

Hypophosphatasia is characterized by defective mineralization of bone and/or teeth in the presence of low activity of serum and bone alkaline phosphatase. Clinical features range from stillbirth without mineralized bone at the severe end to pathologic fractures of the lower extremities in later adulthood at the mild end. Although the disease spectrum is a continuum, six clinical forms are usually recognized based on age at diagnosis and severity of features: Perinatal (severe)...

Background and hypotheses: Urinary C-peptide creatinine ratio (UCPCR) is a new, non-invasive, economical test recommended in differential diagnoses of maturity-onset diabetes of the young (MODY). There are a few studies on this topic. UCPCR values were determined as >0.2 and >0.7 nmol/mmol with a high specificity and sensitivity in differential diagnosis in the previous two studies, the values were evaluated in only three MODY types (HNF1A/HNF4A/GCK-MODY). We investiga...

Background: There is currently an inadequate number of studies on nodule and malignancy development in children and adolescents with Hashimoto thyroiditis (HT).The aim of our study was to determine the rate of thyroid nodules and the nodule malignancy rate in our pediatric HT patients.Material and methods: Patients who were diagnosed with HT between 2004 and 2013 were included in the study. The HT diagnosis was made with the elevation of anti-TPO and ant...

Introduction: Type 1 Diabetes Mellitus (T1DM) is a chronic disease in children and adolescents.There are studies showing that quality of life is affected in T1DM. In our study, we aimed to evaluate the effect of diabetes knowledge levels on quality of life and metabolic status.Methods: Patients aged >10 years who were diagnosed with diabetes mellitus in our clinic and who were given diabetes education and who had reg...

Background: Although it is reported that central precocious puberty (CPP) GnRH analogue (GnRHa) treatment decreases the growth velocity, its relation with IGF-1 is controversial. We aimed to investigate the effects of GnRHa treatment on IGF-1 level and the relationship between IGF-1 level and growth velocity (GV) in our study.Method: Forty-four girls with CPP, who started breast development before the age of 8 years, were enrolled in the study. IGF-1 lev...

Introduction: Childhood obesity is an important public health problem with increasing prevalence. Type 2 diabetes (T2DM) is strongly associated with obesity and metabolic syndrome. Adressing obesity and insulin resistance by drug treatment represents a rational strategy for the prevention of T2DM.Aim: The aim of our study was to evaluate the one year metformin treatment’s long-term effectiveness in children and adolescent.Meth...

Background: Orthopedic complications related to the GH are rare and there is no clear pathological association between the use of GH and these complications. Calcaneal apophysitis is an inflammation of the apophysis and is caused by the constant pull of the Achilles tendon. A literature search did not reveal a similar case of calcaneal apophysitis during GH use.Case presentation: A 13-year-old male receiving GH treatment for isolated GH deficiency presen...

Background: Nutritional rickets continues to be an important health care problem. Its incidence has decreased in our country following the free vitamin D distribution that started in 2005 but it continues to stay on the agenda as a preventable disorder.Aim: Our aim was to evaluate patients diagnosed with nutritional rickets following the vitamin D supplementation program.Method: We evaluated patients diagnosed with nutritional rick...

Objective: AMH decreases by 30% in the first two years following puberty. Although it is known that AMH is associated with FSH and LH, the AMH response to rapid changes in GnRH is not known clearly in puberty. It has been shown that AMH levels in central precocious puberty (CPP) are lower than in premature thelarche (PT), but the levels of AMH in peripheral precocious puberty (PPP) have not been evaluated. The aim of this study was to evaluate the basal an...

Background: Prohormone convertase is an enzyme that converts many biologically inactive prohormones into biologically active peptides. Its deficiency is characterized by deficiency of variable levels in all the hormone systems. In relation to this, postprandial hypoglycemia has been reported but, a case of prohormone convertase deficiency presenting with a diagnosis Type 2 diabetes mellitus has not been previously reported.Case p...